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br Experimental section br Acknowledgements
2023-02-25
Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.
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In our sequential model for tau and A
2023-02-25
In our sequential model for tau and Aβ deposition, we included the tau deposition in the medial temporal E64d in the absence of Aβ deposition, which is a pathological definition of primary age-related tauopathy (PART). Although the tau pathologies in PART and AD are almost identical in their neurop
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Here we found that AMPK directly
2023-02-25
Here we found that AMPK directly phosphorylates EZH2 at Thr311 to disrupt its interaction with SUZ12 and to inhibit PRC2 enzymatic activity, which is supported by the increased expression of PRC2-repressed genes. Furthermore, the T311E-EZH2 mutant that mimics AMPK-mediated phosphorylation status sup
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ERAP has been crystallized in two different conformations
2023-02-25
ERAP1 has been crystallized in two different conformations, wherein the C-terminal domain IV is either closely interacting with domains I/II and enclosing the active site (termed ‘closed’), or is rotated away in a hinge motion which exposes the active site (‘open’). This large motion correlates with
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Ivachtin br Conclusions The following are
2023-02-25
Conclusions The following are the supplementary data related to this article. Author contributions Conflict of interest Funding sources This work was supported by the Canadian Institutes of Health Research [grant: MOP-79470]. Introduction Sperm cells undergo a number of physical and
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Our published data showed that in mouse heart
2023-02-25
Our published data showed that, in mouse heart, the protein level of WDR1 was highest during the embryonic stage, but became progressively decreased to a constant level from birth to adulthood (Yuan et al., 2014), indicating an important role of WDR1 in embryonic heart development. However, function
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Two patients developed diffuse mesangio proliferative glomer
2023-02-25
Two patients developed diffuse mesangio-proliferative glomerulonephritis (DMPG) postoperatively, presenting as nephrotic syndrome and benign haematuria, respectively. DMPG has been reported in an adult patient with thymomatous MG following thymectomy [35], and various types of glomerulonephritis hav
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br Dihydrotestosterone in adult fish and frogs br New perspe
2023-02-25
Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance
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AR-M 1896 mg The first natural product described as
2023-02-25
The first natural product described as 5-LO inhibitor was the polyphenol nordihydroguaiaretic AR-M 1896 mg from the Mexican dessert plant Larrea divaricata in 1981 (Bokoch and Reed, 1981), short after the initial identification of 5-LO in 1979 (Borgeat and Samuelsson, 1979). Long time before mPGES-
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During the year study period of
2023-02-25
During the 4-year study period, 19.9% of men in the dutasteride group developed prostate cancer as compared to 25.1% in the placebo group, which represents an absolute risk Oligomycin A of 5.1% for men taking dutasteride (P first two years of the study had remained in the study until the end (agains
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Roles of Aurora kinases in directly activating multiple onco
2023-02-25
Roles of Aurora kinases in directly activating multiple oncogenic pathways and promoting proliferation as well as transformation have also been demonstrated. Aurora-A has been shown to up-regulate telomerase reverse transcriptase mRNA through c-myc [26]. The kinase was also implicated in activating
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Because of the formation of phosphoenzyme intermediates the
2023-02-25
Because of the formation of phosphoenzyme intermediates, the enzymatic Fmoc-Thr(tBu)-OH of P-ATPases can be divided into steps that include a kinase activity, by which an aspartate residue on the enzyme is phosphorylated, and a phosphatase activity, by which the phosphoenzyme is dephosphorylated. An
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br Conclusions and perspectives In view of the evidences
2023-02-22
Conclusions and perspectives In view of the evidences supporting that DPQ sale MAS receptors mediate the effects of AT1 antagonists (Iwai et al., 2012, Ohshima et al., 2014, Pernomian et al., 2015, Schuchard et al., 2015), the prime targets from the perspectives on future directions in the inter
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br Acetaldehyde One of the most
2023-02-20
Acetaldehyde One of the most common environmental aldehydes is acetaldehyde (CH2CHO). Acetaldehyde, which is highly volatile, has been classified as a Group I human carcinogen by the International Agency for Research on Cancer [30]. Aldehydes can form DNA adducts, including ring-open forms of cro
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br Methods br Results br
2023-02-20
Methods Results Discussion Chronic stress renders individuals vulnerable to diseases, and this effect might be, at least partially, mediated by stress hormone-induced immunosuppression. Therefore, investigating the effects of catecholamines on immune SB 225002 is of high relevance. We hypot
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