• AKT activity is also self

  2025-01-09

  

  AKT activity is also self-limiting through its substrate GSK3β; the kinase activity of which is negatively regulated by AKT phosphorylation (Fig. 3; Li, Liu, & Gao, 2009). GSK3β activation results in phosphorylation and subsequent ubiquitin mediated degradation of PHLPP (Li et al., 2009). AKT activa

• Nrf br AhR br Nrf

  2025-01-08

  

  Nrf2 AhR Nrf2 and AhR: friends or foes for energetic metabolism? Perspectives in carcinogenesis upon xenobiotic exposure Acknowledgements Introduction Integration of endogenous and exogenous signals via appropriate receptors is at the core of biological differentiation and adaptive r

• To investigate the potential link

  2025-01-08

  

  To investigate the potential link between Gβγ and MT assembly in vivo, cultured NIH3T3 and PC12 cells were used. The role of Gβγ in MT assembly was demonstrated using nocodazole, a MT depolymerizing drug [14]. We found that Gβγ was preferentially bound to MTs in NIH3T3 and PC12 cells and treatment w

• br Conclusions br Acknowledgments This research was funded

  2025-01-08

  

  Conclusions Acknowledgments This research was funded by the National Science Foundation Committee (NSFC) of China (Nos. 81171058 and 81471146) and Capital Development Scientific Research in China (Nos. 2011-5001-04 and 2014-4-5013). We are grateful for all of the participants who donated blood

• Epithelial mesenchymal transition EMT is the

  2025-01-08

  

  Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical selonsertib cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and reprogram

• Young disease transitioning B Sle

  2025-01-08

  

  Young disease-transitioning B6·Sle1 mice show partial loss of leukocyte Axl versus B6 controls (data not shown). Further, BMDM from diseased B6·Sle1.Yaa mice do not express detectable levels of ADAM10 and TACE (ADAM17) but do express basal levels of Axl similar to wild type B6-derived BMDM (Suppleme

• br In vivo visualization of aromatase with positron emission

  2025-01-08

  

  In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high Nelfinavir photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the living body

• The current literature clearly states

  2025-01-08

  

  The current literature clearly states that there are no widely adopted standardized methods to determine the total antioxidant capacity of foods or biological samples. One should consider the antioxidant reaction mechanism in system to determine the most appropriate methods for the measurement. It h

• br Diabetic retinopathy Diabetic retinopathy is a severe sig

  2025-01-07

  

  Diabetic retinopathy Diabetic retinopathy is a severe sight-threatening complication associated with diabetes mellitus. It is one of the most common causes of preventable blindness in the world. The risk of developing microvascular diabetic complications increases in diabetic patients with an inc

• Circular dichroism CD provides useful information about prot

  2025-01-07

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light Silodosin spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the commonly

• br The lipoxygenase pathway in diseases of the

  2025-01-07

  

  The 12/15-lipoxygenase pathway in diseases of the nervous system Conclusions and future perspectives Arachidonic Wortmannin and other polyunsaturated fatty acids, and their lipid metabolites, play very important roles in human health and disease. This review has outlined the functions of 12- a

• br Conclusion P gingivalis expresses various

  2025-01-07

  

  Conclusion P. gingivalis expresses various exopeptidases, i.e., DPP4, DPP5, DPP7, DPP11, PtpA, and AOP, in periplasmic space, which produce di- and tri-peptides from most oligopeptides. This oligopeptide processing step is important as an extracellular event in the aldehyde dehydrogenase inhibito

• We also measured macrophage infiltration and CLS

  2025-01-07

  

  We also measured macrophage infiltration and CLS presence in peri-gonadal AT from db/db mice and controls. CLS are morphological features within AT that are accurate indicators of adipocyte death and macrophage infiltration [56]. An earlier study showed that CLS macrophages account for >90% of the t

• NF-κB modulators library br Disclosures br Author contributi

  2025-01-07

  

  Disclosures Author contributions Grants This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute MERIT Award R37 HL040696 to J.A.F. Acknowledgments Introduction The AGC kinases, named after the protein A, G and C kinases, are an evolutionaril

• Perhaps the discovery of this linkage has served to catapult

  2025-01-07

  

  Perhaps the discovery of this linkage has served to catapult much of the work on ABCA1, leaving its family member in need of a relationship with a defined human pathology. In this regard, there is by now a quite mature literature that suggests that ABCA2 may have been overlooked in terms of its impo

15435 records 25/1029 page Previous Next First page 上5页 2122232425 下5页 Last page