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We have previously reported alterations of the thymus in
2023-05-26
We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center bibn (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesting that autoreact
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Our outcrossing data confirmed that ACL and ACL have importa
2023-05-26
Our outcrossing data confirmed that ACL1 and ACL2 have important temporal and spatial functions in ascospore delimitation in G. zeae. When each ACL deletion mutant was used as male for outcrossing, nuclear division and spore delimitation were not properly progressed in most asci. Ascospores that con
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Findings of the present study provide a molecular mechanism
2023-05-26
Findings of the present study provide a molecular mechanism for the elevated ASK1 expression in obesity and how it may be functionally linked to whole-body insulin resistance. The role our findings assign to increased E2F1 in upregulating ASK1 parallels the capacity of this transcription factor to r
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We further evaluated the possibility whether letrozole media
2023-05-26
We further evaluated the possibility whether letrozole mediates its effect through diverting the pathway towards 5α-DHT and further to 3α-Diol. For this purpose, we measured the concentrations of 5α-DHT and 3α-Diol in mice hippocampus and found that letrozole elevated both 5α-DHT and 3α-Diol levels
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br Material and methods br Results
2023-05-26
Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential Oxaliplatin for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginas
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As regards LEPR Sun et
2023-05-26
As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) polym
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The fluorescence in a fluorescent
2023-05-25
The fluorescence in a fluorescent antibiotic can be derived either from functional groups with intrinsic fluorescence in an existing antibiotic, or via synthetic conjugation of a fluorophore to an antibiotic core to enable visualisation. Attachment of fluorophore to an antibiotic should ideally not
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Since primitive societies plants herbs and seeds rich
2023-05-25
Since primitive societies, plants, herbs and seeds, rich in phytochemicals, were used due to their benefits in human health. These molecules were shown to present a diverse array of action mechanisms, including antioxidant activity, enzyme stimulation, hormones mimicking and by interfering with DNA
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Testosterone can be converted into estrogens by aromatase ac
2023-05-25
Testosterone can be converted into estrogens by aromatase action. Aromatase is encoded by CYP19, belongs to cytochrome P450 superfamily, and synthesizes estradiol (E2) and estrone (E1) from testosterone and androstenedione respectively (Fig. 1). Aromatase is expressed in the ORS of anagen hair folli
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Introduction Glaucoma consists of a group of eye
2023-05-25
Introduction Glaucoma consists of a group of eye diseases showing a broad spectrum of clinical presentation and unknown aetiologies, that lead to a permanent loss of visual function due to the death of retinal ganglion Ropivacaine HCl and damage of the optical nerve. It is well accepted that a crit
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Tissue distribution showed that ctrp was abundantly
2023-05-25
Tissue distribution showed that ctrp9 was abundantly expressed in the kidney of male and female tilapia. In mice, the Ctrp9 was identified in adipose tissue, and the expression levels were higher in females than that of males (Wong et al., 2009). Recent studies indicated that Ctrp9 was also expresse
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Although the immobilization by histidine tag exhibits effect
2023-05-25
Although the immobilization by histidine tag exhibits effectiveness in oriented enzyme immobilization, it still faces some challenges [31]. On one hand, some unnecessary metal-binding proteins that interfere with the combination between the target protein and the supports or the additional interacti
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We also investigated the transmittance of actin polymerized
2023-05-25
We also investigated the transmittance of actin polymerized with and without ABP. The presence of actin in the solution results in an increment in turbidity as other proteins provided UCF 101 receptor features [21], [32]. While G-actin showed a transmittance peak positioned at 241 nm, F-actin exhib
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hydroxydopamine OHDA is a selective catecholaminergic
2023-05-25
6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and
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Previously several genes such as cytokine
2023-05-25
Previously, several genes such as cytokine (Lyu and Park, 2007), cell motility-associated genes (Schotterl et al., 2017), transforming growth factor-β (TGF-β), TGF-β receptor II which is a cell surface receptor with serine/threonine kinase activity (Jiang et al., 2014, Schotterl et al., 2017), cell
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