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According to its major function as master regulator of BA
2022-08-12
According to its major function as master regulator of BA homeostasis, FXR has been shown to have a specific tissue distribution; it is expressed along the entire gastrointestinal tract with a peak in the liver and ileum, as well as in the kidney, and adrenal glands [30], [66], [135]. Low FXR expres
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As demonstrated by Bayliss Bayliss myogenic response is the
2022-08-11
As demonstrated by Bayliss Bayliss, [22] myogenic response is the ability of the blood vessels to contract in response to intraluminal pressure elevation. This is intrinsic to VSMCs, particularly in small arteries (dimeter BIX 02565 polymerization within VSMCs in response to increased intravascular
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In general FPSs require Mg or
2022-08-11
In general, FPSs require Mg2+ or Mn2+ as a cofactor for GPP and FPP synthesis. Co2+ also acts as a cofactor in EuFPSs, as in the case for PcFPS and Abies grandis FPS [29], [44]. Co2+ enhanced the activity of EuFPS1 more than the activity of EuFPS2: Mg2+, Mn2+ and Co2+ had approximately the same effe
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LSD also contributes to the regulation of specific programs
2022-08-11
LSD1 also contributes to the regulation of specific programs of gene expression in postmitotic, fate-committed neurons. Perhaps its most specialized role is in the complex series of epigenetic regulatory events that permit each olfactory sensory neuron to express one and only one of the thousands of
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Introduction Histamine Imidazolyl ethylamine is an important
2022-08-11
Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric signal transducer and activator of transcription 6 fragment secretion, neuromodulation, regulation of immune function, cell proliferation a
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br Acknowledgments br Introduction Lung cancer is a common b
2022-08-11
Acknowledgments Introduction Lung cancer is a common but extremely perilous cancer, with approximately 733,000 new incidences reported annually in China [1]. Lung cancer ranks highest in the causes of tumor-related mortality, accounting for approximately one quarter of all cancer deaths [2]. N
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y15 synthesis A revolution in cancer immunotherapy has recen
2022-08-11
A revolution in cancer immunotherapy has recently emerged with the development of novel immunomodulatory antibodies, classified as immunostimulatory agonist monoclonal y15 synthesis (mAbs) or checkpoint blocking mAbs. CD40/CD40L, as an important costimulatory pathway, mediates a broad spectrum of s
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br Methods br Involvement of
2022-08-11
Methods Involvement of HO-1 in rheumatic diseases Therapeutic strategy targeted HO-1 Based on the researches focusing on the effect of HO-1 in rheumatic diseases, amount of approaches targeting regulation of HO-1 have been arising (See Table 1 for summary). It has been shown that different
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The obtained sequence was deposited in GenBank
2022-08-11
The obtained sequence was deposited in GenBank under accession number MG703576; it showed a 99% identify with sample HE817764, reported as Demodex cornei, and with JF784000, reported as D. canis. Molecular and phylogenetic analyses and the morphological characteristics helped to rule out D. cornei.
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However HDACi can also increase the acetylation of
2022-08-11
However, HDACi can also increase the acetylation of other transcription factors that regulate p65 transcriptional activity. The HDACi-induced activation of p65 can be negated by acetylated STAT1, which can specifically bind to p65 and inhibit its transcriptional activity 81, 82, 83. Interestingly, a
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In this precancerous condition though cancer develops
2022-08-11
In this precancerous condition, though cancer develops from the epithelium, the subepithelial connective tissue also play crucial biological role in pathogenesis and progression to malignancy. In this context it may be noted that some recent reports addressed the problem of the mechanical interactio
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Following our initial observation of an unexpected increase
2022-08-11
Following our initial observation of an unexpected increase in the maximal rates of cGMP formation by NO-stimulated sGC in the presence of cytosolic PCA preparations [15], we attempted to purify, identify and characterize the responsible protein(s). The purification protocol described in the present
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br Rho family GTPases are molecular switches
2022-08-11
Rho-family GTPases are molecular switches; most which cycle from an ‘on’ GTP bound state to an ‘off’ GDP bound state, driven by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins) respectively. Association with lipid membranes through a lipid (farnesyl or geranylgerany
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Earlier we have shown relationship between cytotoxicity and
2022-08-11
Earlier, we have shown relationship between cytotoxicity and receptor degeneration in TRAM 39 synthesis having specific neurotransmitter receptors (Siddiqui et al., 2008). In the present study, exposure to 4-HNE reduced expression of DA-D2 receptors in PC12 cells which was found to be concentration
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Furthermore the role of GSK in the pathogenesis of inflammat
2022-08-11
Furthermore, the role of GSK-3 in the pathogenesis of inflammation has been widely documented as it accompanies inflammatory conditions such as diabetes mellitus, mood disorders, Alzheimer’s disease, cancer (Jope et al., 2007), and has been associated with atherothrombotic CVD events. However, anoth
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