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The monomer composition and the
2022-01-26
The monomer composition and the variation in the cryogelation process can result in cryogels with slightly different properties. The adequate characterization of these matrices is advisable in the studies aiming a better understanding of flow inside its structure and also the interactions between th
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Shikonin To synthesize the azaindole based compound Suzuki c
2022-01-26
To synthesize the 7-azaindole based compound , Suzuki coupling of 6-chloro-7-azaindole with 4-CFO-phenylboronic Shikonin was carried out in the presence of Pd(dppf)Cl·CHCl to supply biaryl in quantitative yield (). Iodination at the C-3 position resulted 3-iodo-7-azaindazole . Alkylation of the -
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Following optimization chemicals which were considered as
2022-01-26
Following optimization, 31 chemicals, which were considered as the skin sensitizers and non-sensitizers in LLNA studies, were studied for their potential of β-galactosidase suppression (Table 2). The detailed information on test chemicals used were given in Table 1. With optimum cell densities, E. c
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Liver is the house for
2022-01-26
Liver is the house for a variety of xenobiotic-metabolizing Agarose GPG/ME that produce reactive oxygen species as well as reactive metabolites (Johansson et al., 2009; Noh et al., 2017; Puntarulo and Cederbaum, 1998). When the enzymes act upon pre- or pro-haptens, the chemicals would be activated
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br Chemistry All the title
2022-01-26
Chemistry All the title molecules were generally synthesized using the procedures shown in Scheme 1, Scheme 2, Scheme 3 [17,18,23,24]. The key 2-chloropyrimidine intermediate 11 was prepared according to our previously reported method via subsequent formylation, reduction, and nucleophilic substi
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br Acknowledgment br Introduction Non steroidal
2022-01-26
Acknowledgment Introduction Non-steroidal anti-inflammatory drugs (NSAIDs) are widely utilized to treat pain and inflammation [1], but their chronic use is hindered by a variety of potentially serious adverse events that include gastrointestinal (GI) mucosal lesions, bleeding and perforations
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JMJD C is another JmjC
2022-01-26
JMJD1C is another JmjC domain protein discovered as a putative oncogene in shRNA screens in MLL-AF9-, HOXA9-, and AML1-ETO-driven AML 40, 41, 42. Depletion of JMJD1C decreased the frequency of LICs by inducing their differentiation and impaired the growth and establishment of leukemia in serial tran
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br The HDC knockout mouse as a pathophysiological model
2022-01-26
The HDC knockout mouse as a pathophysiological model of TS The implication of a hypomorphic allele of the Hdc gene as a rare cause of TS (Ercan-Sencicek et al., 2010) created a rare opportunity for the generation of a pathophysiologically grounded model of the disorder. Modeling pathophysiology o
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Many studies have reported on the association between GST ge
2022-01-26
Many studies have reported on the association between GST gene polymorphisms and pulmonary disorders but with controversial results [7]. In the present study, on comparing results of GSTP1 gene polymorphism among the studied COPD patient groups, it was found that heterozygote mutation was significa
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The absolute requirement for substrate prephosphorylation ra
2022-01-26
The absolute requirement for substrate prephosphorylation raised the possibility that short phosphorylated peptides might serve as selective substrate competitive inhibitors. A set of phosphorylated peptides patterned after known GSK-3 substrates was generated and shown to inhibit GSK-3 in vitro in
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ipa chemical mg These findings raise the question of
2022-01-25
These findings raise the question of what mechanism of beta cell proliferation is induced by short-term HF diet feeding. Gene expression profiling of isolated islets from mice fed a HF diet for 1 week revealed that expression levels of downstream genes of Foxm1 were coordinately upregulated (Fig. 5)
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Cx has been shown to be serine
2022-01-25
Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa Cefepime Dihydrochloride Monohydrate [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction propert
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LPCs have been previously described as potential
2022-01-25
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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Liposomes that are less than
2022-01-25
Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by Parathyroid Hormone (1-34), bovine (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Ev
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To efficiently develop bioactive ligands even
2022-01-25
To efficiently develop bioactive ligands even if the structural information of the target protein is unknown, we have presented a three-dimensional structural diversity-oriented strategy based on structural properties of a chiral cyclopropane. Our strategy has allowed us to design and synthesize a s
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