• We have previously shown that the antinociceptive effect of

  2024-12-10

  

  We have previously shown that the antinociceptive effect of tramadol, an analgesic that, like paracetamol is able to increase serotonin levels within CNS, is potentiated or antagonized respectively by a 5-HT1A/B nonspecific NMS-1286937 blockade or activation (Rojas-Corrales et al., 2000). Moreover,

• br Acknowledgments br Introduction Hypospadias is a common c

  2024-12-10

  

  Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,

• While the yeasts and see Glossary each contain only one

  2024-12-10

  

  While the yeasts and (see Glossary) each contain only one Aurora homolog, Ipl1p (increase in ploidy 1) and Ark1 (Aurora-related kinase 1), respectively 5, 6, , and Xenopus laevis contain two Aurora kinases: Aurora A and Aurora B [4]. Mammals have three Aurora kinases, A, B, and C (Figure 1). In an

• Fig summarizes the oxidative metabolism

  2024-12-10

  

  Fig. 1 summarizes the oxidative metabolism of arachidonic Tenovin-1 by lipoxygenases cyclooxygenases and cytochrome P450. Lipoxygenases in humans are expressed in a tissue-specific fashion: 5-LOX is mainly expressed in leukocytes, 12-LOX in platelets, and 15-LOX-1 in reticulocytes, eosinophils, and

• ATM is generally regarded to

  2024-12-10

  

  ATM is generally regarded to be the principal mediator of the G1 muscarinic receptor antagonists checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular cont

• Arginases from several species and tissues have been found t

  2024-12-10

  

  Arginases from several species and tissues have been found to be inhibited by amino acids [51]. In the present study, monocarboxyilic amino acids with five or more carbon atoms such as ornithine, lysine, valine, leucine and isoleucine inhibited CL-ARG. The results revealed that as the amino Ibandron

• Apelin APJ triggers a variety of cellular signaling pathways

  2024-12-10

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 si

• The crucial role of AP in

  2024-12-10

  

  The crucial role of AP-1 in establishing and maintaining cell type-specific gene expression programs and cell identity is further apparent during reprogramming of mouse embryo fibroblasts (MEFs) into iPSCs with either Oct4/Sox2/Klf4/cMyc (OSKM ) factors , or chemicals . Using ATAC-seq to profile chr

• That increased longevity was not the

  2024-12-10

  

  That increased longevity was not the exclusive result of blood pressure reduction. This was demonstrated by analysis of life-long, whole body deletion of AT1A receptors in normotensive mice. These animals exhibited a very significant increase in lifespan when compared to wild- type mice [159], [160]

• Second the phosphorylation events e

  2024-12-09

  

  Second, the phosphorylation events (e.g., α-Thr172 and β-Ser108) needed for AMPK activation by small molecules binding at the ADaM or other sites remains unclear. Within the β-GBD, phosphorylation of β1-Ser108 was shown to be required for the activation by small molecules binding in the ADaM site, s

• TUG-770 br Author contributions br Financial disclosures br

  2024-12-09

  

  Author contributions Financial disclosures Acknowledgements We thank Ms. Eva So for the editorial assistance. This work was supported by grants from the National Natural Science Foundation of China (No. 81622015, 81571042 and 81501143) and the National Basic Research Program of China (No. 2

• Circular dichroism CD provides useful information about prot

  2024-12-09

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light Beauvericin spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the common

• MSG model is well characterized

  2024-12-09

  

  MSG model is well characterized and widely used because it is not influenced by dietary components and because it mimics a lesion in the arcuate nucleus and lateral hypothalamus that can occur in chronic obese patients (Moraes et al., 2009, Purkayasta and Cai, 2013). High fat fed diet is amongst the

• AR is an enzyme involved in conversion of glucose into

  2024-12-09

  

  AR is an enzyme involved in conversion of glucose into sorbitol using NADPH as a cofactor [46]. This AR polyol pathway generates sorbitol accumulation and NADPH depletion. NADPH participates in detoxification via glutathione (GSH) reductase pathway [47]. Therefore, reduction of NADPH attenuates remo

• In the search for more specific inhibitors of uptake

  2024-12-09

  

  In the search for more specific inhibitors of uptake2, Iversen and Salt (1970) speculated that steroids may potentiate the actions of catecholamines on vascular smooth muscle by inhibiting uptake2-mediated catecholamine clearance of the transmitters. They went on to demonstrate that a variety of ste

15475 records 43/1032 page Previous Next First page 上5页 4142434445 下5页 Last page