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L-161,982 Our experimental results demonstrated http www ape
2021-12-20
Our experimental results demonstrated marked variability in antioxidant defenses and oxidative damage in Crassostrea gigas between the visceral mass and the gill after the treatments by rifampicin and verapamil through determining the changes of the activity of SOD and POD and MT content. It has bee
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It is widely acknowledged that CpG methylation of the promot
2021-12-20
It is widely acknowledged that CpG methylation of the promoter regions of some genes plays an important regulatory role in transcriptional regulation and in the establishment and maintenance of cell type-specific gene expression (Li, 2002, Jaenisch and Bird, 2003). This study obtained multiple lines
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br Materials and methods br
2021-12-20
Materials and methods Results Discussion Ghrelin is required for maintenance of glucose homeostasis under fasting conditions, and GHSR-null mice have low fasting blood glucose levels [5], [9]. In this study, we found that restoration of GHSR in nodose ganglion neurons rescued low fasting bl
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cediranib br Contributions br Acknowledgements This research
2021-12-20
Contributions Acknowledgements This research was supported by Natural Sciences and Engineering Research Council (NSERC) Discovery grant No. 341538 and Ontario Graduate Scholarships to HM and VS. Introduction Sexual size dimorphism describes size difference between male and female individua
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Interestingly GAL has also been shown to
2021-12-20
Interestingly, GAL has also been shown to be co-expressed and/or secreted in luteinizing hormone releasing hormone (LHRH) (Merchenthaler et al., 1991, Marks et al., 1994) and kisspeptin (KISS) neurons (Porteous et al., 2011). Furthermore, GAL was shown to stimulate luteinizing hormone (LH) secretion
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Glucose metabolic pathways are well defined but the
2021-12-20
Glucose metabolic pathways are well defined but the subcellular organization of these pathways is poorly understood in liver and kidney. Several factors affect the net flux of gluconeogenesis and allow the Cyclic Pifithrin-α hydrobromide to respond to physiological changes [1]. Ovadi and Srere have
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Here we report a new human genetic disorder
2021-12-20
Here, we report a new human genetic disorder in a patient with hypoalgesia, altered fear and memory symptoms, and a non-anxious disposition. This disorder is attributable to co-inheritance of a microdeletion in a novel pseudogene and a known FAAH hypomorphic SNP. The microdeletion is flanked by repe
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Several lines of evidences suggest that the biological featu
2021-12-20
Several lines of evidences suggest that the biological features of PCs are different from other CLL/SLL RK-33 in the lymph node: the tumor cells in the PCs have been shown to accumulate cytogenetic abnormalities [1, 4] and aberrant expression of oncogene and tumorsuppressor microRNAs (miRs) [5, 6].
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The proposed contributory role of endogenous histamine via a
2021-12-20
The proposed contributory role of endogenous histamine via activation of H1 receptor in the locomotor sensitization induced by caffeine was further ratified by H1 receptor antagonism during the induction phase and subsequently its effect on expression to locomotor sensitization induced by caffeine.
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Preadipocytes are capable of differentiating into lipid
2021-12-18
Preadipocytes are capable of differentiating into lipid-laden mature adipocytes. Lipid droplets are a prominent morphological feature of mature adipocytes, which is accumulated and maintained during adipocytes differentiation [26]. In this study, rHhip treatment increased lipid accumulation, as well
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galactoside The rationale for developing HDACi as anticancer
2021-12-18
The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and galactoside arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematolog
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br Experimental br Acknowledgment br
2021-12-18
Experimental Acknowledgment Introduction Hepatitis C virus (HCV) belongs to Flaviviridae, is a blood-borne pathogen which infects about 180 million individuals throughout the world; most of the cases lead to end stage liver diseases, fibrosis, cirrhosis and hepatocellular carcinoma (Choo et
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br Consequence physiological function of ROS dependent inhib
2021-12-18
Consequence/physiological function of ROS-dependent inhibition of GSNOR Plants response to environmental changes induced by abiotic and biotic factors by enhanced accumulation of ROS resulting in temporary imbalance of the cellular redox homeostasis. This as oxidative stress/burst termed event tr
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The soluble receptor for advanced glycation end products
2021-12-18
The soluble receptor for advanced glycation end products has been already studied in physiological and pathological pregnancy. In accordance to our previous studies we showed increased sRAGE serum levels in women with threatening premature labor [15] and we described a negative correlation of sRAGE
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In contrast to short term effects long term exposure
2021-12-18
In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty Cy7.5 NHS ester (non-sulfonated) oxidation cycle [13], decreased NADPH content [14], endoplasm
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