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br Materials and methods br
2021-12-06
Materials and methods Results Discussion Zn2+ is an extremely abundant transition metal in the synaptic vesicles of hippocampal glutamatergic mossy fibers and remains a key factor in the modulation of neuronal plasticity (Assaf and Chung, 1984). Disruption of Zn2+ homeostasis is associated
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The ultimate success of multimodal probe
2021-12-06
The ultimate success of multimodal probe in the inflammation imaging will be dependent on simplicity in synthesis (combining various modules without protection/deprotection), ease of optimization of pharmacological properties (linker group with tunable PEG moiety), co-registration of macroscopic and
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emodin A common feature of ferroptosis is the iron dependent
2021-12-06
A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty emodin phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which results in PUFA f
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The more important effect of pitolisant is
2021-12-06
The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced HO-3867 receptor release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic tee
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br Methods br Involvement of HO in rheumatic
2021-12-06
Methods Involvement of HO-1 in rheumatic diseases Therapeutic strategy targeted HO-1 Based on the researches focusing on the effect of HO-1 in rheumatic diseases, amount of approaches targeting regulation of HO-1 have been arising (See Table 1 for summary). It has been shown that different
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br Conclusion The present study provides evidence
2021-12-06
Conclusion The present study provides evidence to suggest that the ingestion of acetate as a way to augment cellular pools of acetyl-CoA and influence histone acetylation, does not replicate the epigenetic effects of the prebiotic B-GOS®. Furthermore, acetate feeding does not influence olanzapine
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Here we investigate the structural and biochemical
2021-12-06
Here we investigate the structural and biochemical properties of the N-GTPase domain of p190RhoGAP-A. We determine the crystal structure and find that N-GTPase adopts an extended GTPase-like fold with six unique inserts that seem to preclude its ability to bind typical GAP, GEF, or LY2584702 molecu
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Further explorations at the ortho
2021-12-06
Further explorations at the ortho- and meta-positions of the phenyl in the tail proceeded on the basis of the preliminary results. First, we investigated the fluorine group at the meta- (13p) and ortho-positions (13q) of the phenyl group, with both compounds being slightly less potent than 13o. Surp
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The potential therapeutic actions of GHSR in the central ner
2021-12-06
The potential therapeutic actions of GHSR in the central nervous system has been in the limelight lately. Peripheral administration of GHSR agonists have been shown to inhibit oxidative stress, apoptosis, proinflammatory cytokine production, microglia activation, mitochondrial dysfunction, and excit
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br Voltage dependent anion channel VDAC is a ubiquitous
2021-12-06
Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially
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G quadruplex structures can be resolved by helicases Consist
2021-12-04
G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer neomycin sulfate receptor [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and
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d mannitol br Other strategies for ferroptosis In addition t
2021-12-04
Other strategies for ferroptosis In addition to ROS-generating and GPX4 inactivating nanomaterials, small molecules and genetic manipulation targeting key factors in the ferroptosis pathway have also been tested for their anticancer effects [39,47,48]. Among a myriad of proteins involved in ferro
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br Statistical analysis The mean standard deviation median r
2021-12-04
Statistical analysis The mean, standard deviation, median, range, frequency, and percentage were used for data description. The chi-square (x2) test was used for analyses the differences in categorical variables in the 2-way table. Overall survival (OS) was defined as the time interval between t
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br Acknowledgments Work in SI s laboratory is supported
2021-12-04
Acknowledgments Work in SI’s laboratory is supported by grant IM 20/4-1 from the Deutsche Forschungsgemeinschaft, Bonn (Germany) and grant EKFS 2012_A309 from the Else Kröner Fresenius Stiftung, Bad Homburg (Germany). FW’s group is supported by the Dr Vaillant Foundation and the Dutch Burns Found
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In summary we propose a model that
2021-12-04
In summary, we propose a model that explains the possible mechanism the HULC mediates activation of HBV in liver cancer Papain (Fig. 8). In the model, HULC promotes the expression of miR-539 by stimulating HBx-co-activated STAT3. Then, miR-539 down-regulates APOBEC3B, leading to an increase of HBV c
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