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First identified in as the second mammalian
2021-10-23
First identified in 1982 as the second mammalian glutathione peroxidase [23], we and Stockwell's group demonstrated in 2014 that the selenoperoxidase GPX4 is the key upstream regulator of ferroptosis [12], [13]. The role of GPX4 as the main regulator in the ferroptotic process is based on its unique
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The molecular mechanism of gliotransmitter release is not fu
2021-10-23
The molecular mechanism of gliotransmitter release is not fully understood until now, and previous studies have emphasized that the elevation of [Ca2+]i triggers vesicular Imeglimin hydrochloride of glutamate. Parpura et al. reported that the essential role of Ca2+ release from internal stores in g
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This study is intriguing for several reasons For
2021-10-23
This study is intriguing for several reasons. For acute pancreatitis and acute hepatitis, the early impact of inflammatory cell activation has recently been highlighted and macrophages seem to play a critical role in the disease initiation and severity., , To activate the NLRP3 inflammasome, a 2-ch
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The recently de orphaned G protein coupled receptor GPCR
2021-10-23
The recently de-orphaned G-protein coupled receptor (GPCR), GPR55, is activated endogenously by L-α-lysophosphatidylinositol (LPI), a lipid signaling molecule, as well as N-arachidonoyl glycine (NAGly) and numerous endo, phyto, and synthetic cannabinoids (Oka et al., 2007, Henstridge et al., 2010, H
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To further investigate if GPR was the functional target of
2021-10-23
To further investigate if GPR40 was the functional target of these phenylpropiolic px12 analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK293-GPR40 cell
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A number of experimental data declare
2021-10-23
A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in proton pump inhibitors and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari an
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Young et al described the role of adenine
2021-10-23
Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c
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Human Glucocorticoid Receptor hGR was first
2021-10-23
Human Glucocorticoid Receptor (hGR) was first cloned in 1985 (Hollenburg et al., 1985). It is a modular protein comprised of an N-terminal trans-activating domain (NTD), a C-terminal ligand-binding domain (LBD) and a central DNA- binding domain (DBD). The DBD is highly conserved and has two zinc fi
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The Growth Hormone Secretagogue Receptor GHSR also known
2021-10-23
The Growth Hormone Secretagogue Receptor (GHSR), also known as the ghrelin receptor, is a G protein-coupled receptor (GPCR) expressed widely throughout the body and brain, with particular enrichment in Cyclopamine regions concerned with homeostatic and motivational function such as the hypothalamus
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br Materials and methods br Results br Discussion Ghrelin
2021-10-23
Materials and methods Results Discussion Ghrelin is required for maintenance of glucose homeostasis under fasting conditions, and GHSR-null mice have low fasting blood glucose levels [5], [9]. In this study, we found that restoration of GHSR in nodose ganglion neurons rescued low fasting bl
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VS strategies have been building
2021-10-23
VS strategies have been building momentum in G4 drug discovery both as a low-cost enrichment step and as a lead development step in the discovery pipeline, which our laboratory has previously discussed [31]. Whereas traditional HTS methods rely on obtaining and screening hundreds or thousands of com
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br Role of funding source br Conflict of
2021-10-22
Role of funding source Conflict of interest Acknowledgements We thank F. Blaskovits and P. Kesner for technical assistance. This project was supported by operating grants from the Canadian Institutes of Health Research (CIHR) to X. Zhang (MOP123249) and the National Natural Science Foundati
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Dual H H receptor antagonists developed by
2021-10-22
Dual H1/H3 receptor antagonists developed by GlaxoSmithKline have also reached clinical trials at various stages. These candidates are useful for alleviating the symptoms associated with allergic rhinitis(Daley-Yates et al., 2012). GSK-1004723, 4-[(4-chlorophenyl)methyl]-2-( (2R)-1-[4-(4- [3-(hexahy
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Spatial localization of zGC and zGCAP transcripts by in
2021-10-22
Spatial localization of zGC and zGCAP transcripts by in situ hybridization was detected in the ONL. No transcripts were detected in the outermost periphery of the photoreceptor cell layer adjacent to the marginal zone. This region is described as the area of cone genesis and maturation [29], which f
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Zerumbone mg The observed glucose intolerance and elevated f
2021-10-22
The observed glucose intolerance and elevated fasting blood glucose in this study is in consonance with earlier study (Ferris and Kahn, 2012). These have been the common features of GC exposure and are not unexpected. Previous researches that reported IR during GC exposure have shown controversy con
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