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In the past few years neuroprotection via
2021-08-09
In the past few years, neuroprotection via GLP-1R activation has been shown in several animal models of stroke, Alzheimer's, Parkinson's, Huntington's, ALS and traumatic XAP044 injury. This research field is rapidly growing and several reviews have been recently published (Darsalia et al., 2014b, F
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PPM-18 Recently naphthoquinone derivatives have shown promis
2021-08-09
Recently, naphthoquinone derivatives have shown promising results as antiparasitic lead compounds [28]. Conjugated hybrid compounds could be an effective path to discovery of new drugs by associating two different pharmacophore groups with different mechanisms of action in a single molecule [29,30],
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Ingested folate needs to be chemically modified in order
2021-08-09
Ingested folate needs to be chemically modified in order to become a one carbon donor for cell metabolism. Firstly, folate turns to dihydrofolic orexins (DHF), it is then converted into tetrahydrofolate (THF) by the dihydrofolate reductase enzyme (DHFR) and finally converted into N5, N10-methylene
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br Materials and methods br Results br Discussion
2021-08-09
Materials and methods Results Discussion In this study we characterized in more detail the interrelationship between the expression levels of the B. malayi Bm-cpl-3 and Bm-cpl-6 cysteine proteases and the fitness of Wolbachia, and consequently that of the parasite. Our present in vitro data
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Prostaglandins PGs are lipid mediators that exhibit a
2021-08-09
Prostaglandins (PGs) are lipid mediators that exhibit a variety of physiological properties by interacting specific G protein-coupled receptors (GPCRs) [10]. PGD2 is synthesized from PGH2 through two distinct PGD synthases; lipocalin-type PGD synthase (L-PGDS) and hematopoietic PGD synthase (H-PGDS)
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Both anxiogenic and antinociceptive effects produced by CRF
2021-08-09
Both anxiogenic and antinociceptive effects produced by CRF seem to be selective for the CRF1 receptor, since intra-dPAG microinjection of ASV 30, a CRF2 receptor antagonist, altered neither the anxiety nor the antinociception response. Intra-dPAG ASV 30 was also unable to prevent the anxiogenic (ob
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Interestingly ASV infusion in the dRN of saline
2021-08-09
Interestingly, ASV-30 infusion in the dRN of saline pre-treated rats had no effect on anxiety-like behaviors. This result may be due to the saline pre-treated group exhibiting relatively low levels of anxiety-like behaviors (when compared to saline pre-treated rat of the first experiment that were n
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Bearing in mind that temperamental
2021-08-09
Bearing in mind that temperamental traits are genetically determined, in the present study we have chosen to investigate COMT and OPRM1 gene polymorphisms related to stimulation of the nervous system, which is extremely important in combat sports. The μ-opioid receptor gene OPRM1 is located on the
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br Material and methods br Discussion First
2021-08-09
Material and methods Discussion First, we investigated cannabis use, and results showed that the lifetime prevalence of cannabis use in our sample was 29.63%, with a significant difference between males (73.8% of the abusers) and females (26.2%). Moreover, the mean age and age at onset were si
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As noted earlier while exogenously
2021-08-09
As noted earlier, while exogenously administered BChE can protect against OP toxicity, its efficacy is limited by clearance of the protein from the circulation within a few days. A number of investigations have attempted to increase the circulation time of ChEs by chemical modification, gene transfe
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All of the studies referred to above
2021-08-09
All of the studies referred to above were on microvillous membrane from hSTB; however, there is little information regarding conductances in the basal membrane. Illsley and Sellers, using a fluorescent technique, determined the relative permeabilities of cations and chloride in basal membrane vesicl
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To better understand the mechanism
2021-08-09
To better understand the mechanism of splicing in CLCN1, we began by constructing a minigene spanning exons 5–7 of CLCN1, resulting in the synthetic CLCN1 (5–7) minigene. We also established a new assay using real-time reverse transcription (RT)-PCR, which can distinguish between splicing variants b
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br Materials and methods br
2021-08-09
Materials and methods Results Discussion Taken together with our previous report, our current data demonstrate induction of Chk in monocytes by IL-3, IL-4, IL-13, and GM-CSF ((Musso et al., 1994) and Fig. 1, Fig. 2, Fig. 3, Fig. 4). Chk Oxaliplatin is also inducible by stem cell factor or
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Alverine Citrate br Conclusions br Declaration of interest b
2021-08-06
Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads
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Introduction Pain is frequently the first clinical symptom o
2021-08-06
Introduction Pain is frequently the first clinical symptom of head and neck carcinoma. Indeed, pain is the initial reason leading ∼70% of cancer patients to seek professional assistance (Lam & Schmidt, 2011; Rettig & D’Souza, 2015; Schmidt, 2014). Clinically, cancer-induced facial pain can be evoke
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