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br Cytokine profile in MPN
2021-07-29
Cytokine profile in MPN: Results from experimental investigation Cytokines are small molecules constituted by proteins or glycoproteins, which regulate the immune cell function and the immune system. They are secreted mainly by immune 4-HQN synthesis but also by other cells such as epithelial ce
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entospletinib One strategy which is different
2021-07-29
One strategy which is different from the above is to isolate a similar enzyme to the one under study which will not be recognized by the antibody of the original protein. This approach will lead to prolonging an enzyme’s activity. For example, a novel variant of Carboxypeptidase G2 (CPG2), which has
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To determine the time course
2021-07-29
To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour Asiatic acid were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggesting that
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bicuculline Cubic equations of state CEoS are
2021-07-29
Cubic equations of state (CEoS) are particularly popular due to their simplicity and relatively good accuracy in predicting vapour-liquid equilibrium and liquid-liquid equilibrium for small, non-polar, non-associating molecules, such as light hydrocarbons. CEoS can match the phase boundaries (L/LL a
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The proposed FDIR technique is presented in the following
2021-07-29
The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the Ac-DEVD-pNA receptor environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be esti
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Initially studies of GPCRs predominantly assessed the signal
2021-07-28
Initially, studies of GPCRs predominantly assessed the signalling pathways downstream of receptors on the cell surface. There is now an understanding that GPCRs can localize to and signal from various intracellular compartments, such as the nucleus (reviewed in [40]). These intracellular pools of re
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In this study we detected the PAX FOXO
2021-07-28
In this study, we detected the PAX3/7–FOXO1 fusion Apelin-13 in 50% of the ARMS samples, 40% PAX3–FOXO1 and 10% PAX7–FOXO1. This detection confirmed the histological diagnosis and adds to its new information that can be useful in the prognosis evaluation of ARMS patients, since the patients with PA
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The synthetic route chosen for the preparation of the
2021-07-28
The synthetic route chosen for the preparation of the substrates 18 is shown in Scheme 3. Commercially available 4-aminobenzyl alcohol 13 was found to be relatively unstable to storage and hence it was prepared immediately before use by reduction of the readily available and inexpensive 4-nitrobenzy
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In conclusion our data represents a step
2021-07-28
In conclusion, our data represents a step forward in terms of clarifying the role of I/D polymorphism of ACE and VNTR polymorphism of eNOS and G1793A, C677T and A1298C polymorphism of MTHFR in pathophysiology of psoriasis in Pakistani patients. It will help in better understanding of the disease pro
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Tropical theileriosis is caused by the apicomplexan parasite
2021-07-28
Tropical theileriosis is caused by the apicomplexan parasite Theileria annulata which is transmitted by a tick vector from the genus Hyalomma in cattle (Echebli et al., 2014, Li et al., 2014). Theileria parasites invade the leukocytes by sporozoites secreted from the vector, schizonts mature into me
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To assess whether the described cooperation between the EGFR
2021-07-28
To assess whether the described cooperation between the EGFR and FGFR receptors was relevant at the clinical level, we determined the effect on progression-free survival of FGFR1 expression in patients with adenocarcinoma who were receiving erlotinib or gefitinib. As we had observed EGFR-FGFR1 coope
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br EBV Infection Epstein Barr
2021-07-28
EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt's lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). Th
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A key inciting event in atherosclerosis is the
2021-07-28
A key inciting event in atherosclerosis is the deposition of circulating low-density lipoprotein (LDL) in the subendothelial space of major arteries. In the subendothelium, native LDL is no longer protected by circulating antioxidants and is oxidatively modified to oxidized LDL (OxLDL) [5]. OxLDL is
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br Methods br Results br Discussion Skin
2021-07-28
Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific imidazoline organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Li
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After incorporation of random nucleotides by TdT
2021-07-28
After incorporation of random Pioglitazone receptor by TdT during heavy-chain rearrangements, both TdT and pol λ may perform in trans polymerase activity (in unknown proportions), whereas synthesis of the complementary strand can only be achieved by pol λ using its gap-filling activity, which TdT la
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