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Our results suggest that formation of DDR b
2021-06-15
Our results suggest that formation of DDR1b clusters may be important for and precede receptor phosphorylation. Indeed, while DDR1b clustering was readily detected (by YFP signal) 30 min after collagen administration, phosphorylated DDR1 species at Y513 (present in the IJXM) were evident after 4 h o
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br Results and discussion A
2021-06-15
Results and discussion A systematic search for genes encoding H+-PPases was carried out by PCR using genomic DNA from a wide range of protozoa as templates and degenerate oligonucleotides, designed from amino Parthenolide domains conserved in H+-PPases of higher plants and the proteobacterium R.
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The methods used for cytokine analysis such as ELISA or
2021-06-15
The methods used for cytokine analysis, such as ELISA or multiplex systems could also influence the concentrations of cytokines analysed. It is therefore crucial to use the same lot of the multiplex analysis kit to make such a comparison [21]. In our study, we ensured that the analysis was performed
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Group B phytocystatins are also expressed in caryopses Altho
2021-06-15
Group B phytocystatins are also expressed in caryopses. Although their expression patterns during germination are similar to those of the group A inhibitors, their expression patterns during seed development vary, indicating that they play different roles in the latter process. The highest levels of
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The annotation is arguably the most
2021-06-15
The annotation is arguably the most important part of analysis, as it enables one to evaluate and interpret the content of the transcriptome assembly. In this context, the non-redundant contigs were initially run in BLAST against the Nr database showing that 55% of them displayed high similarity to
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Sex has been shown to mediate
2021-06-11
Sex has been shown to mediate the relationship between allelic differences in COMT and behavior (Harrison & Tunbridge, 2008). The COMT promoter region contains 2 estrogen response elements (Xie, Ho, & Ramsden, 1999) that can inhibit the formation of COMT (Jiang, Xie, Ramsden, & Ho, 2003). With regar
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pergolide Our module is designed to allow
2021-06-11
Our module is designed to allow in-process measurement of [C]-tracer molar activity (MA, GBq/μmol at EOB) using a pergolide detector with a UV detector at the outlet of the HPLC-portion of the system. In the HPLC chromatogram, peak analysis of the chromatographic data utilized PeakSimple software (
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As mentioned above disruption of Tgif
2021-06-11
As mentioned above, disruption of Tgif1 in mice is associated with dyslipidemia, and here we investigate the effects of overexpression of TGIF1 on expression of the Npc1l1 gene and markers of intestinal cholesterol absorption. Materials and methods Results Discussion In this study, we soug
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As plants can only take up P in an inorganic
2021-06-11
As plants can only take up P in an inorganic orthophosphate form, it was expected that the proportion of orthophosphate P in the OA would be a good indication of the availability of the P in the OA. While the P speciation of the COMP sample could not be determined by deconvolution due to the broadne
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br Most reported binding data are
2021-06-11
Most reported binding data are obtained by performing heterologous competition binding experiments and expressing the results as relative binding affinity (RBA). The constructed binding curves should theoretically be sigmoidal in shape with a Hill slope value of one, for a single ligand binding to
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When women reach the menopause they experience a number
2021-06-11
When women reach the menopause they experience a number of physical complaints such as hot flushes, vaginal dryness and mood changes [1]. Bone loss also becomes manifest at this time [1], [2], but women will often not suffer from back pain before a vertebral fracture occurs. Women who have had one f
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SS is a high grade malignant soft tissue sarcoma accounting
2021-06-11
SS is a high-grade malignant soft tissue sarcoma accounting for 5%–10% of soft tissue sarcomas. After RMS, SS is the most common sarcoma in children, adolescents and young adults [9]. SS originates primarily in the lower (62%) and upper (21%) extremities but may occur at any anatomic site [9], [10].
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In this work we fabricated a kind of multifunctional
2021-06-11
In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic her2 inhibitor copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR effic
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Introduction Neuropathic pain occurs in approximately
2021-06-11
Introduction Neuropathic pain occurs in approximately one-third of patients with diabetes and is refractory to currently available analgesic drugs (Abbott et al., 2011). This painful diabetic neuropathy (PDN) is associated with elevated levels of methylglyoxal (MG; a reactive glucose metabolite) an
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Overall the evidence and the results from in vivo
2021-06-11
Overall, the evidence and the results from in vivo studies clearly indicate that cyclosporine biotransformation can be induced by dasatinib co-administration through induction of CYP3A expression. However, further studies are needed to explore the role of P-gp modulation in DDIs. Conclusion In v
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