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Besides having a remarkable progestogenic effect an addition
2021-02-01
Besides having a remarkable progestogenic effect, an additional characteristic of DRSP is its strong antimineralocorticoid effect and antiandrogenic action [11]. DRSP is characterized by an antimineralocorticoid effect that is stronger when compared to progesterone. The decreasing synthesis of proge
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These findings further extend our knowledge of how P and
2021-02-01
These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a
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ERR is expressed in several
2021-02-01
ERRγ is expressed in several adult and embryonic tissues but its biological role is still largely unknown [21]. Overexpression of ERRγ in breast cancer correlates with a favorable outcome [22]. In addition, ERRγ has been reported to inhibit the growth of prostate tumor 23401 zip code [23]. In this
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br No Evidence for Further ET Receptor Subtypes Further
2021-02-01
No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these
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GSK 2837808A synthesis br A brief history of RBR E s RBR
2021-02-01
A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains: two RING domains (RING1 and RING2) connected via an in-between-RING (IBR) domain [28], [29]. The prediction together with initial observati
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The DNA damage response DDR is a
2021-02-01
The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as gamma-Glu-Cys mg regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been
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The occurrence of three Ag NORs per metaphase and
2021-02-01
The occurrence of three Ag-NORs per metaphase and/or a maximum of three nucleoli per nucleus in most of the varieties may be explained by chromosomal rearrangements or unequal crossing-over events that induce the deletion of the fourth active rDNA loci. Also, the chromosome pair that showed less int
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Two key enzymes play important roles in the bioconversion
2021-02-01
Two key enzymes play important roles in the bioconversion of xylitol from d-arabitol, namely d-arabitol dehydrogenase (ArDH) and NADH-dependent xylitol dehydrogenase (XDH), respectively (Qi et al., 2014). In an earlier study, we developed a high xylitol yield strain by expressing xdh in E. coli BL21
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br Materials and methods br Results
2021-02-01
Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the 6015 following HI is not synchronized enough to yield a large, consistent fluctuation
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Confidence with which data of animal safety toxicity
2021-02-01
Confidence with which data of animal safety/toxicity studies can be translated to human depends upon the knowledge that whether humans would be exposed to similar chemical entities (parent and its metabolites) as the animals exposed during toxicity studies. In this regard, in vitro qualitative evalu
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Taking into account that a PFOS inhibits CRF gene
2021-02-01
Taking into account that: (a) PFOS inhibits CRF gene expression as well as CRF and corticosterone secretion (Pereiro et al., 2014); (b) CRF1r mediates the stimulation of the pituitary ACTH secretion by this neuropeptide (Rivier et al., 2003); (c) corticosterone regulates its own synthesis by a negat
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This study demonstrates that GUL affects multiple pathways p
2021-01-30
This study demonstrates that GUL-1 affects multiple pathways/processes. As GUL-1 is likely to function as an RNA-binding protein, it is conceivable that the mRNAs involved are bound to GUL-1 as part of the regulatory function of the protein. In fact, in S. cerevisiae Ssd1 was shown to bind multiple
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br Discussion The use of carp primary cell cultures proved
2021-01-30
Discussion The use of carp primary cell cultures proved to be a valuable approach to evaluate the piscine immune response. A. hydrophila was a more potent stimulator of NO formation by carp leukocytes compared to commercial LPS often used for leukocyte stimulation (Mustafa and Olson, 1998, Chao e
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Data on optimal hormone formulations routes of administratio
2021-01-30
Data on optimal hormone formulations, routes of administration, doses and duration of hormone use in young women with POF are lacking (Box 1). Transdermal clozapine clozaril administration, which avoids the first-pass hepatic circulation and the increase in inflammatory markers such as C-reactive p
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br Discussion We are reporting a cryptic
2021-01-30
Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in SIS3 exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnormality [6]. Additi
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