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Long stretches of ssDNA have also been observed in rad
2020-04-14
Long stretches of ssDNA have also been observed in rad53-1 mutant Rifapentine under replication stress using EM images (Sogo et al., 2002). Deletion of EXO1, a 5′-to-3′ exonuclease, can suppress the generation of ssDNA detected in rad53-1 mutant cells (Cotta-Ramusino et al., 2005). It was thus prop
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Extracellular uridine can be transported across the cell
2020-04-14
Extracellular uridine can be transported across the cell membrane to enter the nucleotide salvage pathway. A colon cancer cell line supplemented with uridine was capable of growing normally in the presence of 1 μM brequinar (Peters et al., 1992). The supplemented uridine may be transported into the
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Some limitations to our study should be noted
2020-04-14
Some limitations to our study should be noted. First, the sample size of our study was limited. As DDR2 mutations are rare in lung SCC, it is possible that the power of our study was insufficient to detect potential associated factors. Second, a significant proportion of the 271 sequenced patients h
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Tolvaptan br Endothelial mechanotransduction br Apoptosis br
2020-04-14
Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the Tolvaptan network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endothelial cells D
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br Material and methods br Results br Discussion br
2020-04-14
Material and methods Results Discussion Conclusions To conclude, although CPT2 and CPT1 must have co-evolved to establish the carnitine shuttling, these enzymes are the most distantly related carnitine transferases, split early in evolution, during which a switch occurred in their locati
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Goel et al reported study of
2020-04-14
Goel et al. reported study of 7,8-diacetoxy-4-methylcoumarin (DAMC) 63 and its thiocoumarin derivative 7,8-diacetoxy-4-methylthiocoumarin (DAMTC) for their effect on human non-small cell lung cancer A549 cells. The study suggested that the 7,8-diacetoxy-4-methylcoumarin (DAMC) 63 downregulates Bcl-x
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br Bipartite graph br Algorithm
2020-04-14
Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in Fmoc-Arg(Pbf)-OH from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-1A p
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TAPI-1 Cx platin could improve the level of cellular uptake
2020-04-14
Cx-platin could improve the level of cellular uptake and DNA platination, hence triggering distinct DNA damage repair pathways. The data (Fig. 3B, C and D) demonstrated that Cx-platin could increase the foci number of γH2AX in cancer cells, preventing the efficient DSBs repair. This gives a good exp
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In the particular case of metals several authors showed
2020-04-14
In the particular case of metals, several authors showed that AChE inhibition is somewhat contradictory and even questionable (Frasco et al., 2005, Nunes et al., 2005, Sáenz et al., 2010). Uranium is a particular metal, and one that has been shown to complex with several biologically important prote
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Furthermore the determination of downstream
2020-04-14
Furthermore, the determination of downstream target genes induced by CdCl2 is noteworthy and can help to define its underlying carcinogenesis mechanism. Therefore, we evaluated c-fos and c-jun expression which are stimulated by estrogen through ERK/MAPK pathway. These are not only proto-oncogenes wh
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To determine the time course
2020-04-13
To determine the time course of ZD2767P+CPG2 DNA–DNA interstrand cross-link formation, HT29 and LS174T colorectal tumour GSK621 synthesis were exposed to the drug for 10, 30 or 60 min. The levels of DNA interstrand cross-links in HT29 or LS174T cells did not increase with exposure time, suggesting
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Flubendazole br Materials and methods br
2020-04-13
Materials and methods Results Discussion Conclusions First, we replicated the association of DDR1 with SZ in an independent Spanish sample and demonstrated that a SNP-SNP interaction within DDR1 played a role in the association with the disease. Second, we observed that SZ subjects with
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br Endothelial mechanotransduction br Apoptosis br
2020-04-13
Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the Lomerizine HCl australia network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endo
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Many investigators participated in the studies on
2020-04-13
Many investigators participated in the studies on the regulation of the N-Benzylacetamidine hydrobromide mg and experiments indicated that the process was conserved across many eukaryotic species including humans [127]. Because cancer cells exhibit dysregulated cell division along with the presence
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Dimethyl Fumarate receptor In contrast irinotecan has shown
2020-04-13
In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide. One phase II study of 13 heavily pretreated Ewing sarcoma patients demonstrated a response rate of 38% including 2 complete responses (Bisogno et al.,
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