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Introduction Adenosine kinase ADK ATP adenosine phosphotrans
2024-07-20
Introduction Adenosine kinase (ADK; ATP: adenosine 5′-phosphotransferase, EC 2.7.1.20), is isolated from yeast cells by Kornberg for the first time in 1951 [1]. ADK belongs to the ribokinase protein family and is one of the most abundant nucleoside kinases in mammalian tissues [2,3]. As the first i
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integrin signaling pathway Ten strains of lactobacilli TMW
2024-07-20
Ten strains of lactobacilli: TMW 1.1434 (isogenic with strain F19 ), TMW 1.1733 (isolated from fermented food), TMW 1.1628 (isolated from baby feces), TMW 1.1609 (isolated from baby feces), TMW 1.1734 (isolated from fermented food), TMW 1.313 (isolated from non-pasteurized Heineken beer), TMW
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Using constant potential amperometry and electrochemical enz
2024-07-20
Using constant potential amperometry and electrochemical enzyme-based biosensors selective for choline—and, therefore, an accurate readout of Bradykinin acetate release (Baker et al., 2015; Bruno et al., 2006a; Parikh et al., 2004, 2007)—tonic and phasic release of acetylcholine were measured simult
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Phospholipases cleave membrane phospholipids from inflammato
2024-07-20
Phospholipases cleave membrane phospholipids from inflammatory cells, activated platelets, erythrocytes, adipocytes and cancer CI 976 (Aoki et al., 2008, Neidlinger et al., 2006). Several reports have analysed the role of LPA and its receptors in the pathogenesis of RA. Zhao et al. reported that L
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br Autophagy at the Synapse The synapse is a highly
2024-07-20
Autophagy at the Synapse The synapse is a highly specialized neuronal compartment that forms the basic unit of communication between neurons. Communication relies on electrical signals that are propagated down the axon of the presynaptic neuron, where they trigger the quantal release of neurotran
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Another contributor for the G
2024-07-20
Another contributor for the G2/M arrest in A549 and H1299 cells might be p21WAF1/CIP1 which was up-regulated upon ovatodiolide treatment. p21WAF1/CIP1 is a common CDKs inhibitor which blocks RPC1063 G2/M phase progression in various types of cancer cells (Kim et al., 2015, Liberio et al., 2015). It
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There is little question that as we become more
2024-07-20
There is little question that as we become more proficient in the diagnosis of arginase 1 deficiency individuals with intermediary elevations in arginine on newborn screening and partial defects in enzymatic activity will be found. There are no reliable data to determine a safe level of arginine and
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br Valsartan It is another ARB with several reports for
2024-07-20
Valsartan It is another ARB, with several reports for its beneficial effects on CV system both in preclinical and clinical studies. Valsartan treatment has reduced the levels of pentraxin 3, a marker for inflammation and is well tolerated in terms of side effects [17]. In BSCORE study, 90-day sec
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br AR expression in breast
2024-07-20
AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f
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br Materials and methods br Results
2024-07-19
Materials and methods Results Discussion We have in this study used semi-nested degenerative PCR to identify the lipoxygenases expressed in the lung tissue from M. fascicularis and report on the identification of 5- and 12/15-LO transcripts from this tissue. Although we did not find transcr
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br Materials and methods br Results Table presents
2024-07-19
Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed SB202190 homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fold), and HOMA-
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Overexpression of AR in a transgenic mouse model
2024-07-19
Overexpression of AR in a transgenic mouse model leads to a capsular cataract phenotype involving proliferation and formation of a fibrotic plaque of cells reminiscent of cells at the posterior kainate receptors in PCO [17]. To investigate the molecular mechanism that could link AR expression to thi
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Thus we presumed that ALDH A
2024-07-19
Thus, we presumed that ALDH1A3 might play an important role in TMZ-chemoresistance in glioblastoma patients. As we expected, the glioblastoma cell lines and primary glioma 5-Azacytidine were more sensitive to TMZ treatment when ALDH1A3 was inhibited or depleted. Consistently, it has been shown that
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The AChR is composed of five homologous membrane spanning su
2024-07-19
The AChR is composed of five homologous, membrane-spanning subunits. AChRs containing two α, one β, one δ and one γ subunit (AChRγ) predominate during embryonic development and mice lacking AChRγ die at birth (Takahashi et al., 2002). After birth, the AChRγs are replaced during the first 2 postnatal
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Previously we reported that EL Kras mice fed
2024-07-19
Previously, we reported that EL-Kras mice-fed diets rich in omega-6 FAs demonstrated increased pancreatic mast cell infiltration [16]. Significantly, increased infiltration of mast cells into the tumor microenvironment correlates with a poor prognosis [15]. Soucek et al.[25] demonstrated that mast c