• Herein we designed a strategy utilizing the

  2020-06-15

  

  Herein, we designed a strategy utilizing the target-protection method to produce a signal in a system involving fluorescence CuNPs stabilized by dumbbell template DNA (DT DNA) through a locked circle consisting of two poly T loops and a poly (ATTA) stem. In the presence of MTase, DT DNA was modifie

• br Halogenases Enzymatic C H activation leading to

  2020-06-13

  

  Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical

• In the case of high fidelity polymerases we propose that

  2020-06-13

  

  In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this

• There exists a glucose residue in the

  2020-06-13

  

  There exists a glucose residue in the structure of 5. Acid hydrolysis (Supplementary data) followed by TLC comparison with the reference compound as well as GC–MS analysis (l-cysteine methyl ester hydrochloride derivative: tR=22.22min for glucose residue of 5 and 22.46min for the reference compound)

• An important strength of our study

  2020-06-13

  

  An important strength of our study is the use of an elastic net regression model to select the variable and construct the model, which performed ideally in terms of both predictive accuracy and sparsity for the high-dimensional datasets [16]. As a result, the apparent predictive effect of multiple c

• Moreover the imbalance between pro and

  2020-06-13

  

  Moreover, the imbalance between pro and anti-inflammatory cytokine production is present in various types of diseases. The use of substances able to induce anti-inflammatory cytokines could represent an important advance in the therapeutic treatment of a range of diseases. In this context, medicinal

• Henderson et al reported that allergen induced

  2020-06-13

  

  Henderson et al. [20] reported that allergen-induced airway remodeling was blocked by the CysLT1 receptor antagonist montelukast. The development of epithelial thickening and mucus accumulation at relatively small hippo signaling pathway was also suppressed by montelukast. The CysLT2 receptor antago

• No effect on the A production by

  2020-06-13

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured derivative of 5 by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this concentrati

• It is of interest to point

  2020-06-13

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general AI-10-49 synthesis of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 defi

• br Material and Methods br Results and Discussion br

  2020-06-12

  

  Material and Methods Results and Discussion Conclusions Two chemical coupling agents, BTDE and CDI, were used to activate the free hydroxyl groups of plant cellulose powder and OPH from Flavobacterium ATCC 27551 immobilized on modified carriers by covalent linkages. The highest immobilizati

• br Experimental br Results and discussion On

  2020-06-12

  

  Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it prostaglandin receptor is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of t

• MAPKs are a family of phosphorylating enzymes that

  2020-06-12

  

  MAPKs are a family of phosphorylating enzymes that orchestrate various cellular response in proliferation, apoptosis, inflammation, stress response, and energy metabolism [11]. There are at least four major members including extracellular signal-regulated kinase 1 and 2 (ERK1/2), p38 mitogen-activat

• Hinokitiol has versatile abilities as anticancer antimicrobi

  2020-06-12

  

  Hinokitiol has versatile abilities as anticancer, antimicrobial and molecule transport agents and appears to have no developmental toxicity or carcinogenic effects (Imai et al., 2006b). For anticancer activities, it causes apoptosis and Derquantel arrest in many different types of cancers, such as m

• Interestingly our analyses of human

  2020-06-12

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 PKI-587 showed homogeneous high expression of EBI2 compared with Th1 cells, which contained a fraction of ce

• br E E backside interaction

  2020-06-12

  

  E3–E2 backside interaction The E2 possesses an important regulatory interface which is termed its backside as it is opposite to the catalytic cleft that bears the active-site cysteine forming the thioester with SUMOD. This backside site interacts noncovalently with a scaffold SUMOB and was origin

14753 records 764/984 page Previous Next First page 上5页 761762763764765 下5页 Last page