• X-press Tag Peptide: Next-Generation Tools for Dynamic Pr...

  2025-09-26

  Explore how X-press Tag Peptide, a leading N-terminal leader peptide for protein purification, advances research by enabling precise detection and functional analysis of recombinant proteins. This article uncovers novel insights into integrating tag-based purification with investigation of cellular signaling pathways, including mTORC1 and neddylation.

• c-Myc tag Peptide: Advanced Roles in Cellular Regulation ...

  2025-09-25

  Explore the multifaceted roles of the c-Myc tag Peptide in transcription factor regulation, immunoassay optimization, and cancer biology. This in-depth article reveals advanced mechanistic insights and unique research applications that distinguish it from prior content.

• c-Myc tag Peptide: Next-Gen Insights for Oncogenic Pathwa...

  2025-09-24

  Explore the advanced scientific and mechanistic roles of the c-Myc tag Peptide in cancer biology, focusing on its unique ability to dissect proto-oncogene c-Myc regulation and gene amplification. This article provides a deep dive into peptide-enabled research strategies, standing apart with novel perspectives on transcription factor regulation in the context of emerging autophagy and immune signaling findings.

• X-press Tag Peptide: Streamlining Quantitative Protein In...

  2025-09-23

  Explore how X-press Tag Peptide, a versatile N-terminal leader peptide, advances quantitative protein interaction studies and affinity purification using ProBond resin. This article details practical strategies for peptide solubility, detection, and integration with modern post-translational modification research.

• FLAG tag Peptide (DYKDDDDK): Enhancing Precision in Recom...

  2025-09-22

  Explore the critical role o

• X-press Tag Peptide: Optimizing Epitope Tag Strategies in...

  2025-09-19

  Explore the multifaceted role of X-press Tag Peptide as an N-terminal leader peptide for affinity purification and detection in recombinant protein expression. This article examines technical considerations and recent applications, highlighting advances in protein purification tag peptide design and usage.

• X-press Tag Peptide: Enabling Advanced N-Terminal Tagging...

  2025-09-18

  This article explores the X-press Tag Peptide as an N-terminal leader peptide engineered for high-specificity protein purification, focusing on its role in epitope tagging, detection, and controlled cleavage. By integrating recent research advances and technical insights, it highlights how X-press Tag Peptide advances affinity purification using ProBond resin and facilitates robust protein analysis.

• These mutations induce the gene auto

  2025-03-03

  

  These mutations induce the gene auto-activation in 10–40% of adenocarcinomas, triggering the EGFR-signaling pathway in the absence of ligand. That leads to an uncontrolled acceleration of cell proliferation, survival and anti-apoptotic signals (Couraud et al., 2012). The frequency of these mutations

• NLX a k a F or befiradol exhibits

  2025-03-03

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in ep4 antagonist to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Additionally, it

• The anorexic effect observed when AR is

  2025-03-03

  

  The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between

• In the late s Solvay Pharmaceuticals discontinued the Phase

  2025-03-03

  

  In the late ‘90s, Solvay Pharmaceuticals discontinued the Phase 2 development of a promising potent and highly selective A1AR antagonist based on the pyrrolopyrimidine scaffold, SLV320 [43] (2, Chart 1, also named derenofylline; Ki hA1AR = 1 nM), for the treatment of acute heart failure [24]. In the

• Axl has been reported to mediate cell cell adhesion and

  2025-03-03

  

  Axl has been reported to mediate cell-cell adhesion and sphere-growth [11], [18] and to be important for metastasis to secondary organs [12], [14], [20]. We found an Axl-dependent CCRCC-ability of sphere-formation and repopulation after non-adhesive growth. Axl-inhibited cells could not attach to ea

• br Methods br Results br

  2025-03-03

  

  Methods Results Discussion Autotaxin has been shown to have effects on major cell types implicated in OA, notably chondrocytes, osteoblasts, osteoclasts, and synoviocytes, through its enzymatic product LPA [20]. However, a paucity of research exists on the involvement of autotaxin in OA. Fi

• Starting with commercially available or nitropyrazole carbox

  2025-03-01

  

  Starting with commercially available 4- or 5-nitropyrazole-3-carboxylic acid, anilides containing nitro, amino or methylsulfonamido were synthesized. Here, manipulation of the substituents on the pyrazole ring was conducted after the anilide formation (). The ixazomib of the nitro group was perform

• In addition to calpain I

  2025-03-01

  

  In addition to calpain I activity, cathepsin activities have been proven to be linked to apoptotic signaling. Cathepsin B and cathepsin D are two of the most abundant and well-investigated lysosome acid-dependent proteases that are involved in the apoptotic regulation (Ferri & Kroemer, 2001). Cathep

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